Strong rules for nonconvex penalties and their implications for efficient algorithms in high-dimensional regression

We consider approaches for improving the efficiency of algorithms for fitting nonconvex penalized regression models such as SCAD and MCP in high dimensions. In particular, we develop rules for discarding variables during cyclic coordinate descent. This dimension reduction leads to a substantial improvement in the speed of these algorithms for high-dimensional problems. The rules we propose here eliminate a substantial fraction of the variables from the coordinate descent algorithm. Violations are quite rare, especially in the locally convex region of the solution path, and furthermore, may be easily detected and corrected by checking the Karush-Kuhn-Tucker conditions. We extend these rules to generalized linear models, as well as to other nonconvex penalties such as the $\ell_2$-stabilized Mnet penalty, group MCP, and group SCAD. We explore three variants of the coordinate decent algorithm that incorporate these rules and study the efficiency of these algorithms in fitting models to both simulated data and on real data from a genome-wide association study

Advanced control of grid-connected multilevel power electronic rectifiers

Multilevel power electronic converters have been gaining attention due to their ability to supply high amounts of power and to handle high voltage levels. In this dissertation, grid connected AC-DC rectifier application is investigated with different topologies and control scheme. At first, neutral point clamped (NPC) rectifier is employed to transfer power from the grid to the load. The NPC rectifier has two capacitors in order to build multilevel output voltage. However, it causes voltage unbalancing problem. Therefore, the new method has been proposed to regulate each capacitor voltage at the same voltage level. Experimental results show that it is effective to balance capacitor voltages of the NPC and it can improve total harmonic distortion (THD) of the grid current as a result. Furthermore, 7 voltage levels can be achieved by using hybrid multilevel rectifier which consists of an NPC and cascaded H-bridges (CHB). Because the hybrid multilevel rectifier has total 8 capacitors which are completely discharged at first, large inrush currents from the grid might cause hazards. Therefore, the paper develops a pre-charge routine for building it up to steady state operation in which unity power factor control (PFC) and load voltage control are achieved. Finally, multiple reference frame theory (MRF) is used to improve THD of the grid currents when the hybrid multilevel rectifier is connected with distorted grid voltage source. After calculating 5th harmonic of the grid current in real time, the voltage reference for the hybrid multilevel rectifier will be compensated in a feedback loop. Experimental results show validity in improving THD of the grid currents. --Abstract, page iv

Aluminum nitride waveguide beam splitters for integrated quantum photonic circuits

We demonstrate integrated photonic circuits for quantum devices using sputtered polycrystalline aluminum nitride (AlN) on insulator. The on-chip AlN waveguide directional couplers, which are one of the most important components in quantum photonics, are fabricated and show the output power splitting ratios from 50:50 to 99:1. The polarization beam splitters with an extinction ratio of more than 10 dB are also realized from the AlN directional couplers. Using the fabricated AlN waveguide beam splitters, we observe the Hong-Ou-Mandel interference with a visibility of 91.7 +(-) 5.66 %.Comment: 9 pages, 4 figure

ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork

R-loops are formed when replicative forks collide with the transcriptional machinery and can cause genomic instability. However, it is unclear how R-loops are regulated at transcription-replication conflict (TRC) sites and how replisome proteins are regulated to prevent R-loop formation or mediate R-loop tolerance. Here, we report that ATAD5, a PCNA unloader, plays dual functions to reduce R-loops both under normal and replication stress conditions. ATAD5 interacts with RNA helicases such as DDX1, DDX5, DDX21 and DHX9 and increases the abundance of these helicases at replication forks to facilitate R-loop resolution. Depletion of ATAD5 or ATAD5-interacting RNA helicases consistently increases R-loops during the S phase and reduces the replication rate, both of which are enhanced by replication stress. In addition to R-loop resolution, ATAD5 prevents the generation of new R-loops behind the replication forks by unloading PCNA which, otherwise, accumulates and persists on DNA, causing a collision with the transcription machinery. Depletion of ATAD5 reduces transcription rates due to PCNA accumulation. Consistent with the role of ATAD5 and RNA helicases in maintaining genomic integrity by regulating R-loops, the corresponding genes were mutated or downregulated in several human tumors

Large-Area, Highly Sensitive SERS Substrates with Silver Nanowire Thin Films Coated by Microliter-Scale Solution Process

A microliter-scale solution process was used to fabricate large-area, uniform films of silver nanowires (AgNWs). These thin films with cross-AgNWs were deposited onto Au substrates by dragging the meniscus of a microliter drop of a coating solution trapped between two plates. The hot spot density was tuned by controlling simple experimental parameters, which changed the optical properties of the resulting films. The cross-AgNW films on the Au surface served as excellent substrates for surface-enhanced Raman spectroscopy, with substantial electromagnetic field enhancement and good reproducibility

Perfect Absorption and Reflection Modulation Based on Asymmetric Slot-Assisted Gratings without Mirrors

As a perfect graphene absorber without any external mirrors, we proposed asymmetric slot-assisted grating structures supporting two degenerate resonant modes of the guided-mode resonances (GMR) and the quasi-bound states in the continuum (quasi-BIC). The GMR mode functions as an internal mirror in conjunction with the background scattering, while the quasi-BIC, which is responsible for perfect graphene absorption, stems from the horizontal symmetry breaking by an asymmetric slot. By properly shifting the slot center from the grating center, the leakage rate of quasi-BIC can be controlled in such a way as to satisfy the critical coupling condition. We provide a comprehensive study on the coupling mechanism of two degenerate resonant modes for a one-port system mimicking the resonance. We also numerically demonstrated that our proposed grating structures show an excellent reflection-type modulation performance at optical wavelength ranges when doped double-layer graphene is applied. Due to the perfect absorption at the OFF state, a high modulation depth of ~50 dB can be achieved via a small Fermi level variation of ~0.05 eV. To obtain the lower insertion loss at the ON state, the higher Fermi level is required to decrease the graphene absorption coefficient

Phase-Shifted Modulation Strategy for Voltage Balancing in Neutral-Point Clamped Converter

This paper suggests a new method to balance the voltage of the two capacitors in the three-level neutral-point clamped (NPC) converter. The proposed method only needs the information of two capacitor voltages. The two capacitor voltages are fed back to the controller and then the controller generates phase shifting value with which sinusoidal modulation will be adjusted to the left or right. This method has upper and lower modulation signals. The outcome of the closed-loop is a phase compensation which will be applied to the upper and lower modulation signals. By applying the phase compensation in a different direction on the two modulation signals, this method provides voltage balancing. The new voltage balancing technique is verified by simulation and experimental results

A Robust Hybrid Multilevel Rectifier with Adjustable Output Voltage and Variable Load

In order to obtain synergic benefits by using two different semiconductors such as thyristors and IGBTs, hybrid multilevel converters have been studied recently in the literature. In a grid connected application, unity power factor (PF) control and load voltage control should be achieved. The proposed hybrid multilevel rectifier consists of a main neutral point clamped (NPC) and cell cascaded H-bridges (CHB). Each CHB has a floating capacitor. Therefore, in order to reduce costs, the system regulates the floating capacitor voltages without using independent DC power sources. Additionally, a control strategy concerning the voltage unbalance problem on the main NPC is also considered. Under load resistance changes, the hybrid multilevel rectifier accomplishes unity PF and load voltage control as well as the regulation of CHB capacitor voltages. Experimental results combining all mentioned technologies show verification of the robust hybrid multilevel rectifier in a grid connected application

Optical waveguide and cavity effects on whispering-gallery mode resonances in a ZnO nanonail

Spatially resolved cathodoluminescence (CL) study of a ZnO nanonail, having thin shank, tapered neck, and hexagonal head sections, is reported. Monochromatic imaging and line scan profiling indicate that the wave guiding and leaking from growth imperfections in addition to the oxygen deficiency variation determine the spatial contrast of CL emissions. Occurrence of resonance peaks at identical wavelengths regardless of CL-excitation spots is inconsistent with the whispering-gallery mode (WGM) resonances of a two-dimensional cavity in the finite difference time domain simulation. However, three dimensioanl cavity simulation produced WGM peaks that are consistent with the experimental spectra, including transverse-electric resonances that are comparable to transverse-magnetic ones